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Medically Reviewed By:

2026-05-01

Splenic & Renal Artery Stenosis

Also Known As: renal artery stenosis, renovascular hypertension, fibromuscular dysplasia, splenic artery aneurysm, visceral artery stenosis
Splenic and renal artery stenosis refer to narrowings within the arteries supplying the spleen and kidneys, respectively. Renal artery stenosis is a significant and underrecognized cause of secondary hypertension and progressive kidney failure. Splenic artery disease may involve stenosis, aneurysm formation, or thrombosis. Both conditions benefit from vascular evaluation and, in selected patients, revascularization to restore blood flow and protect organ function.


Most people have never heard of the splenic or renal arteries — and that is completely normal. These are blood vessels that carry blood to your spleen and kidneys, and like the arteries in your heart and legs, they can narrow over time. When that happens, your organs may not get the blood flow they need. The good news is that this kind of narrowing can often be treated without major surgery.


Renal Artery Stenosis

Renal artery stenosis is a narrowing of one or both arteries supplying the kidneys, reducing blood flow and triggering the renin-angiotensin system — a hormonal mechanism that raises blood pressure in an attempt to maintain kidney perfusion. The result is renovascular hypertension, which is often severe, difficult to control with medications, and potentially reversible with treatment of the underlying stenosis. In advanced cases, reduced perfusion leads to ischemic nephropathy and permanent kidney damage.

Splenic Artery Disease

The splenic artery is the most common site for visceral artery aneurysm — a localized dilation of the vessel that carries risk of rupture, particularly during pregnancy. Atherosclerotic splenic artery stenosis may cause spleen ischemia or be asymptomatic. Splenic artery aneurysms larger than 2 cm in women of childbearing age or aneurysms of any size with symptoms require intervention.

Diagnosis and Treatment

Duplex ultrasound is the first-line screening test for renal artery stenosis, detecting elevated velocities that indicate significant narrowing. CT angiography provides anatomical detail for treatment planning. Renal artery stenting (percutaneous transluminal angioplasty and stenting) is the preferred revascularization method for atherosclerotic renal artery stenosis, restoring blood flow to the kidney and in selected patients improving blood pressure control. Splenic artery aneurysms are treated with coil embolization or open surgical ligation.

SYMPTOMS

  • Resistant hypertension uncontrolled despite 3 or more medications (renal)
  • Worsening kidney function — especially after starting ACE inhibitor or ARB (renal)
  • Incidentally found splenic artery aneurysm on CT or ultrasound
  • Abdominal pain or left shoulder pain (splenic disease)
  • Often asymptomatic until discovered on imaging

DIAGNOSIS METHODS

  • Duplex Renal Ultrasound +

    First-line screening for renal artery stenosis — detects elevated velocities indicating significant narrowing.

  • CT Angiography +

    Provides anatomical detail for treatment planning.

  • MRI Angiography +

    Non-contrast alternative preserving kidney function.

  • Nuclear Medicine (Captopril Renography) +

    Functional test measuring the kidney's response to captopril to confirm hemodynamically significant stenosis.

TREATMENTS

RELATED CONDITIONS

FREQUENTLY ASKED QUESTIONS

  • Can treating renal artery stenosis cure my high blood pressure? +

    In patients whose hypertension is driven primarily by renal artery stenosis — particularly younger patients without long-standing essential hypertension — revascularization can significantly improve blood pressure control and in some cases allow reduction of antihypertensive medications. The benefit depends on the degree of stenosis, kidney function, and the duration of hypertension.

  • What are the signs of renal artery stenosis? +

    Renal artery stenosis should be suspected in patients with resistant hypertension (blood pressure uncontrolled despite three or more medications), new-onset hypertension in young adults or elderly patients, sudden worsening of previously controlled blood pressure, or worsening kidney function after starting an ACE inhibitor or ARB.